Mark Schumacher, MD, PhD

Director, PARC

Professor and Chief, Division of Pain Medicine

Anesthesia

+1 415 502-7022

Dr. Schumacher's research focuses on the identification of novel analgesic targets in the peripheral nervous system to treat chronic pain without risk of addiction. Currently, he is investigating a class of transcription inhibitors previously used to treat cancer that now show promise to block pain from inflammation and nerve injury.

UCSF Research Profile

Publications:

Peripheral Neuroinflammation and Pain: How Acute Pain Becomes Chronic.

Current neuropharmacology

Schumacher MA

Chemotherapy for pain: reversing inflammatory and neuropathic pain with the anticancer agent mithramycin A.

Pain

Xu Z, Lee MC, Sheehan K, Fujii K, Rabl K, Rader G, Varney S, Sharma M, Eilers H, Kober K, Miaskowski C, Levine JD, Schumacher MA

N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes.

Journal of neuroinflammation

Joffre J, Wong E, Lawton S, Lloyd E, Nguyen N, Xu F, Sempio C, Kobzik L, Zlatanova I, Schumacher M, Klawitter J, Su H, Rabl K, Wilhelmsen K, Yeh CC, Hellman J

Long-Term Trends in Postoperative Opioid Prescribing, 1994 to 2014.

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews

Chen CL, Jeffery MM, Krebs EE, Thiels CA, Schumacher MA, Schwartz AJ, Thombley R, Finlayson E, Rodriguez-Monguio R, Ward D, Dudley RA

Differential methylation and expression of genes in the hypoxia-inducible factor 1 signaling pathway are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors and with preclinical models of chemotherapy-induced neuropathic pa

Molecular pain

Kober KM, Lee MC, Olshen A, Conley YP, Sirota M, Keiser M, Hammer MJ, Abrams G, Schumacher M, Levine JD, Miaskowski C

Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors.

Journal of neuroimmunology

Miaskowski C, Topp K, Conley YP, Paul SM, Melisko M, Schumacher M, Chesney M, Abrams G, Levine JD, Kober KM

Deleterious Effects of Higher Body Mass Index on Subjective and Objective Measures of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors.

Journal of pain and symptom management

Petrovchich I, Kober KM, Wagner L, Paul SM, Abrams G, Chesney MA, Topp K, Smoot B, Schumacher M, Conley YP, Hammer M, Levine JD, Miaskowski C

Transcription factor Sp4 is required for hyperalgesic state persistence.

PloS one

Sheehan K, Lee J, Chong J, Zavala K, Sharma M, Philipsen S, Maruyama T, Xu Z, Guan Z, Eilers H, Kawamata T, Schumacher M

Age-related differences in patient-reported and objective measures of chemotherapy-induced peripheral neuropathy among cancer survivors.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Wong ML, Cooper BA, Paul SM, Abrams G, Topp K, Kober KM, Chesney MA, Mazor M, Schumacher MA, Conley YP, Levine JD, Miaskowski C

Pain Management and Opioid Regulation: Continuing Public Health Challenges.

American journal of public health

Bonnie RJ, Schumacher MA, Clark JD, Kesselheim AS

[EXPRESS] Signaling Pathways and Gene Co-Expression Modules Associated with Cytoskeleton and Axon Morphology in Breast Cancer Survivors with Chronic Paclitaxel-Induced Peripheral Neuropathy.

Molecular pain

Kober K, Schumacher MA, Conley YP, Topp K, Mazor M, Hammer M, Paul S, Levine J, Miaskowski C

Expression of mitochondrial dysfunction-related genes and pathways in paclitaxel-induced peripheral neuropathy in breast cancer survivors.

Molecular pain

Kober KM, Olshen A, Conley YP, Schumacher M, Topp K, Smoot B, Mazor M, Chesney M, Hammer M, Paul SM, Levine JD, Miaskowski C

Phenotypic Characterization of Paclitaxel-Induced Peripheral Neuropathy in Cancer Survivors.

Journal of pain and symptom management

Kober KM, Mazor M, Abrams G, Olshen A, Conley YP, Hammer M, Schumacher M, Chesney M, Smoot B, Mastick J, Paul SM, Levine JD, Miaskowski C

Associations Between Perceived Stress and Chemotherapy-Induced Peripheral Neuropathy and Otoxicity in Adult Cancer Survivors.

Journal of pain and symptom management

Miaskowski C, Paul SM, Mastick J, Abrams G, Topp K, Smoot B, Kober KM, Chesney M, Mazor M, Mausisa G, Schumacher M, Conley YP, Sabes JH, Cheung S, Wallhagen M, Levine JD