Mark Schumacher, MD, PhD

Director, PARC
Professor and Chief, Division of Pain Medicine
+1 415 502-7022

Dr. Schumacher's research focuses on the identification of novel analgesic targets in the peripheral nervous system to treat chronic pain without risk of addiction. Currently, he is investigating a class of transcription inhibitors previously used to treat cancer that now show promise to block pain from inflammation and nerve injury.

UCSF Research Profile


Long-Term Trends in Postoperative Opioid Prescribing, 1994 to 2014.

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews

Chen CL, Jeffery MM, Krebs EE, Thiels CA, Schumacher MA, Schwartz AJ, Thombley R, Finlayson E, Rodriguez-Monguio R, Ward D, Dudley RA

Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors.

Journal of neuroimmunology

Miaskowski C, Topp K, Conley YP, Paul SM, Melisko M, Schumacher M, Chesney M, Abrams G, Levine JD, Kober KM

Deleterious Effects of Higher Body Mass Index on Subjective and Objective Measures of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors.

Journal of pain and symptom management

Petrovchich I, Kober KM, Wagner L, Paul SM, Abrams G, Chesney MA, Topp K, Smoot B, Schumacher M, Conley YP, Hammer M, Levine JD, Miaskowski C

Transcription factor Sp4 is required for hyperalgesic state persistence.

PloS one

Sheehan K, Lee J, Chong J, Zavala K, Sharma M, Philipsen S, Maruyama T, Xu Z, Guan Z, Eilers H, Kawamata T, Schumacher M

Age-related differences in patient-reported and objective measures of chemotherapy-induced peripheral neuropathy among cancer survivors.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Wong ML, Cooper BA, Paul SM, Abrams G, Topp K, Kober KM, Chesney MA, Mazor M, Schumacher MA, Conley YP, Levine JD, Miaskowski C

Pain Management and Opioid Regulation: Continuing Public Health Challenges.

American journal of public health

Bonnie RJ, Schumacher MA, Clark JD, Kesselheim AS

Expression of mitochondrial dysfunction-related genes and pathways in paclitaxel-induced peripheral neuropathy in breast cancer survivors.

Molecular pain

Kober KM, Olshen A, Conley YP, Schumacher M, Topp K, Smoot B, Mazor M, Chesney M, Hammer M, Paul SM, Levine JD, Miaskowski C

Phenotypic Characterization of Paclitaxel-Induced Peripheral Neuropathy in Cancer Survivors.

Journal of pain and symptom management

Kober KM, Mazor M, Abrams G, Olshen A, Conley YP, Hammer M, Schumacher M, Chesney M, Smoot B, Mastick J, Paul SM, Levine JD, Miaskowski C

Associations Between Perceived Stress and Chemotherapy-Induced Peripheral Neuropathy and Otoxicity in Adult Cancer Survivors.

Journal of pain and symptom management

Miaskowski C, Paul SM, Mastick J, Abrams G, Topp K, Smoot B, Kober KM, Chesney M, Mazor M, Mausisa G, Schumacher M, Conley YP, Sabes JH, Cheung S, Wallhagen M, Levine JD

Impact of chemotherapy-induced neurotoxicities on adult cancer survivors' symptom burden and quality of life.

Journal of cancer survivorship : research and practice

Miaskowski C, Mastick J, Paul SM, Abrams G, Cheung S, Sabes JH, Kober KM, Schumacher M, Conley YP, Topp K, Smoot B, Mausisa G, Mazor M, Wallhagen M, Levine JD

Hearing loss and tinnitus in survivors with chemotherapy-induced neuropathy.

European journal of oncology nursing : the official journal of European Oncology Nursing Society

Miaskowski C, Paul SM, Mastick J, Schumacher M, Conley YP, Smoot B, Abrams G, Kober KM, Cheung S, Henderson-Sabes J, Chesney M, Mazor M, Wallhagen M, Levine JD

America's Opioid Epidemic: Supply and Demand Considerations.

Anesthesia and analgesia

Clark DJ, Schumacher MA

N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1.

Journal of immunology (Baltimore, Md. : 1950)

Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K

Chemotherapy-Induced Neuropathy in Cancer Survivors.

Journal of pain and symptom management

Miaskowski C, Mastick J, Paul SM, Topp K, Smoot B, Abrams G, Chen LM, Kober KM, Conley YP, Chesney M, Bolla K, Mausisa G, Mazor M, Wong M, Schumacher M, Levine JD

The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion neurons.

Neuroscience letters

Zavala K, Lee J, Chong J, Sharma M, Eilers H, Schumacher MA

Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons.

Molecular pain

Chu C, Zavala K, Fahimi A, Lee J, Xue Q, Eilers H, Schumacher MA

Cutaneous nerve transection for the management of intractable upper extremity pain caused by invasive squamous cell carcinoma.

Journal of pain and symptom management

Turnbull JH, Gebauer SL, Miller BL, Barbaro NM, Blanc PD, Schumacher MA

Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction.


Eilers H, Cattaruzza F, Nassini R, Materazzi S, Andre E, Chu C, Cottrell GS, Schumacher M, Geppetti P, Bunnett NW

TRPV1 splice variants: structure and function.

Frontiers in bioscience (Landmark edition)

Schumacher MA, Eilers H

Transient receptor potential channels in pain and inflammation: therapeutic opportunities.

Pain practice : the official journal of World Institute of Pain

Schumacher MA

The rat vanilloid receptor splice variant VR.5'sv blocks TRPV1 activation.


Eilers H, Lee SY, Hau CW, Logvinova A, Schumacher MA

Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis.

The Journal of biological chemistry

Andres-Enguix I, Caley A, Yustos R, Schumacher MA, Spanu PD, Dickinson R, Maze M, Franks NP

Isolation of an mRNA binding protein homologue that is expressed in nociceptors.

The European journal of neuroscience

Eilers H, Trilk SL, Lee SY, Xue Q, Jong BE, Moff I, Levine JD, Schumacher MA

The reversal of fentanyl-induced tolerance by administration of "small-dose" ketamine.

Anesthesia and analgesia

Eilers H, Philip LA, Bickler PE, McKay WR, Schumacher MA

The stretch-inactivated channel, a vanilloid receptor variant, is expressed in small-diameter sensory neurons in the rat.

Neuroscience letters

Schumacher MA, Jong BE, Frey SL, Sudanagunta SP, Capra NF, Levine JD

The capsaicin receptor: a heat-activated ion channel in the pain pathway.


Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D

ATP receptors in sickness, pain and death.

Chemistry & biology

Brake A, Schumacher M, Julius D