Joshua Berke, PhD

PARC Core Leader
Professor, Department of Neurology and UCSF Weill Institute for Neurosciences
Director, Alcohol and Addiction Research Group
Neurology
[email protected]

Josh Berke's laboratory at UCSF investigates brain mechanisms involved in learning, motivation and decision-making, and how these mechanisms go awry in disorders such as drug addiction, Parkinson's Disease and Huntington's Disease. (see www.berkelab.org). He is also Director of the Alcohol and Addiction Research Group, and holds the Rudi Schmid Distinguished Professorship in Neurology.

Publications: 

A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors.

Proceedings of the National Academy of Sciences of the United States of America

Duhne M, Mohebi A, Kim K, Pelattini L, Berke JD

Hippocampal representations of alternative possibilities are flexibly generated to meet cognitive demands.

bioRxiv : the preprint server for biology

Comrie AE, Monroe EJ, Kahn AE, Denovellis EL, Joshi A, Guidera JA, Krausz TA, Berke JD, Daw ND, Frank LM

Comment on 'Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation'.

eLife

Taniguchi J, Melani R, Chantranupong L, Wen MJ, Mohebi A, Berke JD, Sabatini BL, Tritsch NX

Dopamine transients follow a striatal gradient of reward time horizons.

Nature neuroscience

Mohebi A, Wei W, Pelattini L, Kim K, Berke JD

Comment on 'Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation'.

bioRxiv : the preprint server for biology

Taniguchi J, Melani R, Chantranupong L, Wen MJ, Mohebi A, Berke J, Sabatini B, Tritsch N

Dual credit assignment processes underlie dopamine signals in a complex spatial environment.

Neuron

Krausz TA, Comrie AE, Kahn AE, Frank LM, Daw ND, Berke JD

Dual credit assignment processes underlie dopamine signals in a complex spatial environment.

bioRxiv : the preprint server for biology

Krausz TA, Comrie AE, Frank LM, Daw ND, Berke JD

Dopamine subsystems that track internal states.

Nature

Grove JCR, Gray LA, La Santa Medina N, Sivakumar N, Ahn JS, Corpuz TV, Berke JD, Kreitzer AC, Knight ZA

Coupling between motor cortex and striatum increases during sleep over long-term skill learning.

eLife

Lemke SM, Ramanathan DS, Darevksy D, Egert D, Berke JD, Ganguly K

High density carbon fiber arrays for chronic electrophysiology, fast scan cyclic voltammetry, and correlative anatomy.

Journal of neural engineering

Patel PR, Popov P, Caldwell CM, Welle EJ, Egert D, Pettibone JR, Roossien DH, Becker JB, Berke JD, Chestek CA, Cai D

Cellular-scale silicon probes for high-density, precisely-localized neurophysiology.

Journal of neurophysiology

Egert DG, Pettibone JR, Lemke SM, Patel PR, Caldwell CM, Cai D, Ganguly K, Chestek CA, Berke J

An expanded palette of dopamine sensors for multiplex imaging in vivo.

Nature methods

Patriarchi T, Mohebi A, Sun J, Marley A, Liang R, Dong C, Puhger K, Mizuno GO, Davis CM, Wiltgen B, von Zastrow M, Berke JD, Tian L

The Degree of Nesting between Spindles and Slow Oscillations Modulates Neural Synchrony.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Silversmith DB, Lemke SM, Egert D, Berke JD, Ganguly K

Dopamine release drives motivation, independently from dopamine cell firing.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Mohebi A, Berke JD

Knock-In Rat Lines with Cre Recombinase at the Dopamine D1 and Adenosine 2a Receptor Loci.

eNeuro

Pettibone JR, Yu JY, Derman RC, Faust TW, Hughes ED, Filipiak WE, Saunders TL, Ferrario CR, Berke JD

Publisher Correction: Dissociable dopamine dynamics for learning and motivation.

Nature

Mohebi A, Pettibone JR, Hamid AA, Wong JT, Vinson LT, Patriarchi T, Tian L, Kennedy RT, Berke JD

Dissociable dopamine dynamics for learning and motivation.

Nature

Mohebi A, Pettibone JR, Hamid AA, Wong JT, Vinson LT, Patriarchi T, Tian L, Kennedy RT, Berke JD

What does dopamine mean?

Nature neuroscience

Berke JD

Sensorimotor Processing in the Basal Ganglia Leads to Transient Beta Oscillations during Behavior.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Mirzaei A, Kumar A, Leventhal D, Mallet N, Aertsen A, Berke J, Schmidt R

(Invited) Carbon Fiber Electrode Array for the Detection of Electrophysiological and Dopaminergic Activity.

ECS Meeting Abstracts

Paras R. Patel, Pavlo Popov, Ali Mohebi, Arif Hamid, Jeffrey Pettibone, Doug Roossien, Brandon Aragona, Dawen Cai, Joshua Berke, Cynthia Chestek

A Pause-then-Cancel model of stopping: evidence from basal ganglia neurophysiology.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Schmidt R, Berke JD

Acetylcholine Release in Prefrontal Cortex Promotes Gamma Oscillations and Theta-Gamma Coupling during Cue Detection.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Howe WM, Gritton HJ, Lusk NA, Roberts EA, Hetrick VL, Berke JD, Sarter M

Arkypallidal Cells Send a Stop Signal to Striatum.

Neuron

Mallet N, Schmidt R, Leventhal D, Chen F, Amer N, Boraud T, Berke JD

Cortical cholinergic signaling controls the detection of cues.

Proceedings of the National Academy of Sciences of the United States of America

Gritton HJ, Howe WM, Mallory CS, Hetrick VL, Berke JD, Sarter M

Mesolimbic dopamine signals the value of work.

Nature neuroscience

Hamid AA, Pettibone JR, Mabrouk OS, Hetrick VL, Schmidt R, Vander Weele CM, Kennedy RT, Aragona BJ, Berke JD

Silk-Backed Structural Optimization of High-Density Flexible Intracortical Neural Probes.

Journal of Microelectromechanical Systems

Fan Wu, Lee W. Tien, Fujun Chen, Joshua D. Berke, David L. Kaplan, Euisik Yoon

Silk-backed structural optimization of high-density flexible intracortical neural probes

IEEE Journal on Microelectromechanical Systems

Wu F, Tien LW, Chen F, Berke J, Kaplan DL, Yoon E.

New roles for the external globus pallidus in basal ganglia circuits and behavior.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Gittis AH, Berke JD, Bevan MD, Chan CS, Mallet N, Morrow MM, Schmidt R

Dissociable effects of dopamine on learning and performance within sensorimotor striatum.

Basal ganglia

Leventhal DK, Stoetzner C, Abraham R, Pettibone J, DeMarco K, Berke JD

Control of basal ganglia output by direct and indirect pathway projection neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Freeze BS, Kravitz AV, Hammack N, Berke JD, Kreitzer AC

Canceling actions involves a race between basal ganglia pathways.

Nature neuroscience

Schmidt R, Leventhal DK, Mallet N, Chen F, Berke JD

Basal ganglia beta oscillations accompany cue utilization.

Neuron

Leventhal DK, Gage GJ, Schmidt R, Pettibone JR, Case AC, Berke JD

Selective inhibition of striatal fast-spiking interneurons causes dyskinesias.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Gittis AH, Leventhal DK, Fensterheim BA, Pettibone JR, Berke JD, Kreitzer AC

Striatal fast-spiking interneurons: from firing patterns to postsynaptic impact.

Frontiers in systems neuroscience

Klaus A, Planert H, Hjorth JJ, Berke JD, Silberberg G, Kotaleski JH

Functional properties of striatal fast-spiking interneurons.

Frontiers in systems neuroscience

Berke JD

Integrating early results on ventral striatal gamma oscillations in the rat.

Frontiers in neuroscience

van der Meer MA, Kalenscher T, Lansink CS, Pennartz CM, Berke JD, Redish AD

Memory formation: from network structure to neural dynamics.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

Feldt S, Wang JX, Hetrick VL, Berke JD, Zochowski M

Local dynamics of gap-junction-coupled interneuron networks.

Physical biology

Lau T, Gage GJ, Berke JD, Zochowski M

Opposite effects of stimulant and antipsychotic drugs on striatal fast-spiking interneurons.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Wiltschko AB, Pettibone JR, Berke JD

State-dependent plasticity of the corticostriatal pathway.

Neuroscience

Stoetzner CR, Pettibone JR, Berke JD

Corticostriatal Interactions during Learning, Memory Processing, and Decision Making.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Pennartz CM, Berke JD, Graybiel AM, Ito R, Lansink CS, van der Meer M, Redish AD, Smith KS, Voorn P

Functional clustering algorithm for the analysis of dynamic network data.

Physical review. E, Statistical, nonlinear, and soft matter physics

Feldt S, Waddell J, Hetrick VL, Berke JD, Zochowski M

Striatal versus hippocampal representations during win-stay maze performance.

Journal of neurophysiology

Berke JD, Breck JT, Eichenbaum H

Procedural Learning: Striatum.

Encyclopedia of Neuroscience

J.D. Berke

Uncoordinated firing rate changes of striatal fast-spiking interneurons during behavioral task performance.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Berke JD

Functional structure from dynamic clustering of spike train data.

BMC neuroscience

Sarah Feldt, Jack Waddell, Vaughn L Hetrick, Joshua D Berke, Michal Zochowski

The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump.

Biochemical and biophysical research communications

Sgambato-Faure V, Xiong Y, Berke JD, Hyman SE, Strehler EE

Oscillatory Entrainment of Striatal Neurons in Freely Moving Rats.

Neuron

Joshua D. Berke, Murat Okatan, Jennifer Skurski, Howard B. Eichenbaum

Oscillatory entrainment of striatal neurons in freely moving rats.

Neuron

Berke JD, Okatan M, Skurski J, Eichenbaum HB

Drug addiction and the hippocampus.

Science (New York, N.Y.)

Berke JD, Eichenbaum HB

Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin.

Neuron

Berke JD, Sgambato V, Zhu PP, Lavoie B, Vincent M, Krause M, Hyman SE

A complex program of striatal gene expression induced by dopaminergic stimulation.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Berke JD, Paletzki RF, Aronson GJ, Hyman SE, Gerfen CR

Acute effects of cocaine on human brain activity and emotion.

Neuron

Breiter HC, Gollub RL, Weisskoff RM, Kennedy DN, Makris N, Berke JD, Goodman JM, Kantor HL, Gastfriend DR, Riorden JP, Mathew RT, Rosen BR, Hyman SE

Activation of striatum and amygdala during reward conditioning: An FMRI study.

NeuroImage

H.C. Breiter, J.D. Berke, W.A. Kennedy, B.R. Rosen, S.E. Hyman