Allan Basbaum, PhD

PARC Advisory Board Member
Professor and Chair, Department of Anatomy
Anatomy
+1 415 502-1399

Following upon our extensive earlier studies of the CNS circuits through which opioids exert their analgesic effects, our laboratory now examines the mechanisms through which tissue and nerve injury produce changes in the peripheral and central nervous system that result in persistent pain. In parallel studies we examine the circuits through which pruritogens generate itch. The hallmark of our work is a multidisciplinary approach to the problem, using molecular, neuroanatomical, pharmacological and behavioral analyses in wild type and genetically-modified mice, including knockouts and Cre- or reporter-expressing mice generated in our laboratory. By combining these studies with an analysis of the functional properties of molecularly-defined neurons, these studies examine the extent to which pain and itch circuits segregate or converge at the level of spinal cord interneurons and projection neurons. Also of great interest are the mechanisms through which monocytes, including peripheral macrophages and spinal cord microglia, contribute to the persistent pain following nerve injury. With a view to overcoming the neurological consequences of peripheral nerve damage, we also studied the effects of transplanting embryonic cortical GABAergic precursor cells into the spinal cord. We have demonstrated that the cells integrate synaptically and functionally into host neural circuits and can ameliorate the persistent pain and itch associated with nerve damage, effectively treating what we consider to be the "disease" of neuropathic pain. And recently using long-term calcium imaging of spinal cord and cortical neurons in awake, behaving mice we are examining the brain and spinal cord circuits and mechanisms through which pain and itch percepts are generated as well as the mechanisms through which different general anesthetics exert their analgesic action. Below are several comprehensive reviews that we have published on the topics described above.

Publications: 

Long-term optical imaging of the spinal cord in awake behaving mice.

Nature methods

Ahanonu B, Crowther A, Kania A, Rosa-Casillas M, Basbaum AI

Neuroanatomy of the nociceptive system: From nociceptors to brain networks.

International review of neurobiology

Motzkin JC, Basbaum AI, Crowther AJ

It all began in Issaquah 50 years ago.

Pain

Ballantyne JC, Basbaum AI

Regulatory T cell-derived enkephalin imparts pregnancy-induced analgesia.

bioRxiv : the preprint server for biology

Midavaine É, Moraes BC, Benitez J, Rodriguez SR, Braz JM, Kochhar NP, Eckalbar WL, Domingos AI, Pintar JE, Basbaum AI, Kashem SW

Large library docking for cannabinoid-1 receptor agonists with reduced side effects.

bioRxiv : the preprint server for biology

Tummino TA, Iliopoulos-Tsoutsouvas C, Braz JM, O'Brien ES, Stein RM, Craik V, Tran NK, Ganapathy S, Liu F, Shiimura Y, Tong F, Ho TC, Radchenko DS, Moroz YS, Rosado SR, Bhardwaj K, Benitez J, Liu Y, Kandasamy H, Normand C, Semache M, Sabbagh L, Glenn I, Irwin JJ, Kumar KK, Makriyannis A, Basbaum AI, Shoichet BK

Docking for EP4R antagonists active against inflammatory pain.

Nature communications

Gahbauer S, DeLeon C, Braz JM, Craik V, Kang HJ, Wan X, Huang XP, Billesbølle CB, Liu Y, Che T, Deshpande I, Jewell M, Fink EA, Kondratov IS, Moroz YS, Irwin JJ, Basbaum AI, Roth BL, Shoichet BK

International Association for the Study of Pain publications over the 50-year span.

Pain

Davis KD, Basbaum AI, Bushnell MC, Yarnitsky D, Fields HL

IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis.

Science immunology

Fassett MS, Braz JM, Castellanos CA, Salvatierra JJ, Sadeghi M, Yu X, Schroeder AW, Caston J, Munoz-Sandoval P, Roy S, Lazarevsky S, Mar DJ, Zhou CJ, Shin JS, Basbaum AI, Ansel KM

Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA: Methodological limitations and convergent results.

Neuroscience and biobehavioral reviews

Linguiti S, Vogel JW, Sydnor VJ, Pines A, Wellman N, Basbaum A, Eickhoff CR, Eickhoff SB, Edwards RR, Larsen B, McKinstry-Wu A, Scott JC, Roalf DR, Sharma V, Strain EC, Corder G, Dworkin RH, Satterthwaite TD

Pain and itch processing in aged mice.

The journal of pain

Braz JM, Hamel K, Craik V, Rodriguez-Rosado S, Bhardwaj K, Jewell M, Bieri G, Villeda SA, Basbaum AI

Long-term optical imaging of the spinal cord in awake, behaving animals.

bioRxiv : the preprint server for biology

Ahanonu B, Crowther A, Kania A, Casillas MR, Basbaum A

Structure-based discovery of conformationally selective inhibitors of the serotonin transporter.

Cell

Singh I, Seth A, Billesbølle CB, Braz J, Rodriguiz RM, Roy K, Bekele B, Craik V, Huang XP, Boytsov D, Pogorelov VM, Lak P, O'Donnell H, Sandtner W, Irwin JJ, Roth BL, Basbaum AI, Wetsel WC, Manglik A, Shoichet BK, Rudnick G

Paradoxical increases in anterior cingulate cortex activity during nitrous oxide-induced analgesia reveal a signature of pain affect.

bioRxiv : the preprint server for biology

Weinrich JA, Liu CD, Jewell ME, Andolina CR, Bernstein MX, Benitez J, Rodriguez-Rosado S, Braz JM, Maze M, Nemenov MI, Basbaum AI

Structure-based discovery of nonopioid analgesics acting through the a2A-adrenergic receptor.

Science (New York, N.Y.)

Fink EA, Xu J, H?bner H, Braz JM, Seemann P, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM, Tolmachova NA, Moroz YS, Huang XP, Kalyanaraman C, Gahbauer S, Chen G, Liu Z, Jacobson MP, Irwin JJ, Bouvier M, Du Y, Shoichet BK, Basbaum AI, Gmeiner P

History of Spinal Cord "Pain" Pathways Including the Pathways Not Taken.

Frontiers in pain research (Lausanne, Switzerland)

Basbaum A

Structural imaging studies of patients with chronic pain: an anatomic likelihood estimate meta-analysis.

Pain

Henn AT, Larsen B, Frahm L, Xu A, Adebimpe A, Scott JC, Linguiti S, Sharma V, Basbaum AI, Corder G, Dworkin RH, Edwards RR, Woolf CJ, Habel U, Eickhoff SB, Eickhoff CR, Wagels L, Satterthwaite TD

An ACVR1 activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.

Pain

Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC

Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor.

Journal of medicinal chemistry

Levit Kaplan A, Strachan RT, Braz JM, Craik V, Slocum S, Mangano T, Amabo V, O'Donnell H, Lak P, Basbaum AI, Roth BL, Shoichet BK

Structures of the σ2 receptor enable docking for bioactive ligand discovery.

Nature

Alon A, Lyu J, Braz JM, Tummino TA, Craik V, O'Meara MJ, Webb CM, Radchenko DS, Moroz YS, Huang XP, Liu Y, Roth BL, Irwin JJ, Basbaum AI, Shoichet BK, Kruse AC

Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice.

eLife

Kuhn J, Vainchtein ID, Braz JM, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky A, Molofsky A, Basbaum A

Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons.

Proceedings of the National Academy of Sciences of the United States of America

Wercberger R, Braz JM, Weinrich JA, Basbaum AI

Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity.

eLife

Löken LS, Braz JM, Etlin A, Sadeghi M, Bernstein M, Jewell M, Steyert M, Kuhn J, Hamel K, Llewellyn-Smith IJ, Basbaum A

TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.

Proceedings of the National Academy of Sciences of the United States of America

Wang TA, Chen C, Huang F, Feng S, Tien J, Braz JM, Basbaum AI, Jan YN, Jan LY

Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsiveness.

Proceedings of the National Academy of Sciences of the United States of America

Brain Responses to Noxious Stimuli in Patients With Chronic Pain: A Systematic Review and Meta-analysis.

JAMA network open

Xu A, Larsen B, Henn A, Baller EB, Scott JC, Sharma V, Adebimpe A, Basbaum AI, Corder G, Dworkin RH, Edwards RR, Woolf CJ, Eickhoff SB, Eickhoff CR, Satterthwaite TD

Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing.

PloS one

Alvaro CG, Braz JM, Bernstein M, Hamel KA, Craik V, Yamanaka H, Basbaum AI

Convergent neural representations of experimentally-induced acute pain in healthy volunteers: A large-scale fMRI meta-analysis.

Neuroscience and biobehavioral reviews

Xu A, Larsen B, Baller EB, Cobb Scott J, Sharma V, Adebimpe A, Basbaum AI, Dworkin RH, Edwards RR, Woolf CJ, Eickhoff SB, Eickhoff CR, Satterthwaite TD

Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain.

Nature communications

Yu X, Liu H, Hamel KA, Morvan MG, Yu S, Leff J, Guan Z, Braz JM, Basbaum AI

Ablation of spinal cord estrogen receptor a-expressing interneurons reduces chemically-induced modalities of pain and itch.

The Journal of comparative neurology

Tran M, Braz JM, Hamel K, Kuhn J, Todd AJ, Basbaum AI

Spinal cord projection neurons: a superficial, and also deep, analysis.

Current opinion in physiology

Wercberger R, Basbaum AI

GABAergic cell transplants in the anterior cingulate cortex reduce neuropathic pain aversiveness.

Brain : a journal of neurology

Juarez-Salinas DL, Braz JM, Etlin A, Gee S, Sohal V, Basbaum AI

Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion.

Neuron

Meda KS, Patel T, Braz JM, Malik R, Turner ML, Seifikar H, Basbaum AI, Sohal VS

Morphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn.

Pain

Dickie AC, Bell AM, Iwagaki N, Polgár E, Gutierrez-Mecinas M, Kelly R, Lyon H, Turnbull K, West SJ, Etlin A, Braz J, Watanabe M, Bennett DLH, Basbaum AI, Riddell JS, Todd AJ

Pain relief by supraspinal gabapentin requires descending noradrenergic inhibitory controls.

Pain reports

Juarez-Salinas DL, Braz JM, Hamel KA, Basbaum AI

Transition to chronic pain: opportunities for novel therapeutics.

Nature reviews. Neuroscience

Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh TL, Dworkin RH

NaV1.1 inhibition can reduce visceral hypersensitivity.

JCI insight

Salvatierra J, Castro J, Erickson A, Li Q, Braz J, Gilchrist J, Grundy L, Rychkov GY, Deiteren A, Rais R, King GF, Slusher BS, Basbaum A, Pasricha PJ, Brierley SM, Bosmans F

Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits.

Neuron

Wang D, Tawfik VL, Corder G, Low SA, François A, Basbaum AI, Scherrer G

Chemogenetic management of neuropathic pain.

Brain : a journal of neurology

Basbaum A

Neuronal aromatase expression in pain processing regions of the medullary and spinal cord dorsal horn.

The Journal of comparative neurology

Tran M, Kuhn JA, Bráz JM, Basbaum AI

Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release.

Proceedings of the National Academy of Sciences of the United States of America

Zhang C, Medzihradszky KF, Sánchez EE, Basbaum AI, Julius D

Synergistic antipruritic effects of gamma aminobutyric acid A and B agonists in a mouse model of atopic dermatitis.

The Journal of allergy and clinical immunology

Cevikbas F, Braz JM, Wang X, Solorzano C, Sulk M, Buhl T, Steinhoff M, Basbaum AI

Rebuilding CNS inhibitory circuits to control chronic neuropathic pain and itch.

Progress in brain research

Braz JM, Etlin A, Juarez-Salinas D, Llewellyn-Smith IJ, Basbaum AI

Functional Synaptic Integration of Forebrain GABAergic Precursors into the Adult Spinal Cord.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Etlin A, Bráz JM, Kuhn JA, Wang X, Hamel KA, Llewellyn-Smith IJ, Basbaum AI

Peripheral and central neuronal ATF3 precedes CD4+ T-cell infiltration in EAE.

Experimental neurology

Frezel N, Sohet F, Daneman R, Basbaum AI, Braz JM

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.

Nature

Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EA, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans F, King GF, Julius D

Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations.

Pain

Andrews NA, Latrémolière A, Basbaum AI, Mogil JS, Porreca F, Rice AS, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, Iyengar S, Jensen MP, Kennedy JD, Lee N, Levine J, Lidster K, Machin I, McDermott MP, McMahon SB, Price TJ, Ross SE, Scherrer G, Seal RP, Sena ES, Silva E, Stone L, Svensson CI, Turk DC, Whiteside G

Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain.

Nature neuroscience

Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M, Abboud-Werner SL, Lanier LL, Lomvardas S, Basbaum AI

Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli.

PloS one

Bonasera SJ, Schenk AK, Luxenberg EJ, Wang X, Basbaum A, Tecott LH

Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury.

Cell reports

Petitjean H, Pawlowski SA, Fraine SL, Sharif B, Hamad D, Fatima T, Berg J, Brown CM, Jan LY, Ribeiro-da-Silva A, Braz JM, Basbaum AI, Sharif-Naeini R

CT-guided injection of a TRPV1 agonist around dorsal root ganglia decreases pain transmission in swine.

Science translational medicine

Brown JD, Saeed M, Do L, Braz J, Basbaum AI, Iadarola MJ, Wilson DM, Dillon WP

In Memoriam Jean-Marie Besson 1938-2014.

European journal of pain (London, England)

Villanueva L, Bouhassira D, Dickenson T, Basbaum A, Zimmermann M

Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Solorzano C, Villafuerte D, Meda K, Cevikbas F, Bráz J, Sharif-Naeini R, Juarez-Salinas D, Llewellyn-Smith IJ, Guan Z, Basbaum AI

Transplant restoration of spinal cord inhibitory controls ameliorates neuropathic itch.

The Journal of clinical investigation

Braz JM, Juarez-Salinas D, Ross SE, Basbaum AI

Interneurons from embryonic development to cell-based therapy.

Science (New York, N.Y.)

Southwell DG, Nicholas CR, Basbaum AI, Stryker MP, Kriegstein AR, Rubenstein JL, Alvarez-Buylla A

Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn.

Neuron

Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Choudhury P, Betelli C, Cassidy C, Smith K, de Nooij JC, Mennicken F, O'Donnell D, Kieffer BL, Woodbury CJ, Basbaum AI, MacDermott AB, Scherrer G

Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn.

Neuron

Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Choudhury P, Betelli C, Cassidy C, Smith K, de Nooij JC, Mennicken F, O'Donnell D, Kieffer BL, Woodbury CJ, Basbaum AI, MacDermott AB, Scherrer G

A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1.

The Journal of allergy and clinical immunology

Cevikbas F, Wang X, Akiyama T, Kempkes C, Savinko T, Antal A, Kukova G, Buhl T, Ikoma A, Buddenkotte J, Soumelis V, Feld M, Alenius H, Dillon SR, Carstens E, Homey B, Basbaum A, Steinhoff M

Identification of multisegmental nociceptive afferents that modulate locomotor circuits in the neonatal mouse spinal cord.

The Journal of comparative neurology

Mandadi S, Hong P, Tran MA, Bráz JM, Colarusso P, Basbaum AI, Whelan PJ

TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing.

Nature neuroscience

Huang F, Wang X, Ostertag EM, Nuwal T, Huang B, Jan YN, Basbaum AI, Jan LY

Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch.

Neuron

Wang X, Zhang J, Eberhart D, Urban R, Meda K, Solorzano C, Yamanaka H, Rice D, Basbaum AI

Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain.

Neuron

Bráz JM, Sharif-Naeini R, Vogt D, Kriegstein A, Alvarez-Buylla A, Rubenstein JL, Basbaum AI

A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain.

Nature

Bohlen CJ, Chesler AT, Sharif-Naeini R, Medzihradszky KF, Zhou S, King D, Sánchez EE, Burlingame AL, Basbaum AI, Julius D

Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Cavanaugh DJ, Chesler AT, Bráz JM, Shah NM, Julius D, Basbaum AI

Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Cavanaugh DJ, Chesler AT, Jackson AC, Sigal YM, Yamanaka H, Grant R, O'Donnell D, Nicoll RA, Shah NM, Julius D, Basbaum AI

Differential TRPV1 and TRPV2 channel expression in dental pulp.

Journal of dental research

Gibbs JL, Melnyk JL, Basbaum AI

Targeting pain where it resides ... In the brain.

Science translational medicine

Sharif-Naeini R, Basbaum AI

Introducing the Biennial review of pain.

Pain

Mogil JS, Basbaum AI

VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity.

Proceedings of the National Academy of Sciences of the United States of America

Scherrer G, Low SA, Wang X, Zhang J, Yamanaka H, Urban R, Solorzano C, Harper B, Hnasko TS, Edwards RH, Basbaum AI

Olfactory ensheathing glia express aquaporin 1.

The Journal of comparative neurology

Shields SD, Moore KD, Phelps PE, Basbaum AI

Effect of topical 0.5% morphine on postoperative pain after photorefractive keratectomy.

Journal of refractive surgery (Thorofare, N.J. : 1995)

Faktorovich EG, Basbaum AI

Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice.

Cephalalgia : an international journal of headache

Bates EA, Nikai T, Brennan KC, Fu YH, Charles AC, Basbaum AI, Ptácek LJ, Ahn AH

Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors.

Nature

Seal RP, Wang X, Guan Y, Raja SN, Woodbury CJ, Basbaum AI, Edwards RH

Cellular and molecular mechanisms of pain.

Cell

Basbaum AI, Bautista DM, Scherrer G, Julius D

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms.

Proceedings of the National Academy of Sciences of the United States of America

Imamachi N, Park GH, Lee H, Anderson DJ, Simon MI, Basbaum AI, Han SK

Dissociation of the opioid receptor mechanisms that control mechanical and heat pain.

Cell

Scherrer G, Imamachi N, Cao YQ, Contet C, Mennicken F, O'Donnell D, Kieffer BL, Basbaum AI

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli.

Proceedings of the National Academy of Sciences of the United States of America

Cavanaugh DJ, Lee H, Lo L, Shields SD, Zylka MJ, Basbaum AI, Anderson DJ

Inputs to serotonergic neurons revealed by conditional viral transneuronal tracing.

The Journal of comparative neurology

Braz JM, Enquist LW, Basbaum AI

TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Wang X, Ratnam J, Zou B, England PM, Basbaum AI

Change is coming!

Pain

Basbaum AI

Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Neumann S, Braz JM, Skinner K, Llewellyn-Smith IJ, Basbaum AI

Contribution of the Reelin signaling pathways to nociceptive processing.

The European journal of neuroscience

Akopians AL, Babayan AH, Beffert U, Herz J, Basbaum AI, Phelps PE

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.

Proceedings of the National Academy of Sciences of the United States of America

Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P

The menthol receptor TRPM8 is the principal detector of environmental cold.

Nature

Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D

Contribution of substance P and neurokinin A to the differential injury-induced thermal and mechanical responsiveness of lamina I and V neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Mazarío J, Basbaum AI

Spider toxins activate the capsaicin receptor to produce inflammatory pain.

Nature

Siemens J, Zhou S, Piskorowski R, Nikai T, Lumpkin EA, Basbaum AI, King D, Julius D

Tissue injury regulates serotonin 1D receptor expression: implications for the control of migraine and inflammatory pain.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Ahn AH, Basbaum AI

Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Scherrer G, Tryoen-Tóth P, Filliol D, Matifas A, Laustriat D, Cao YQ, Basbaum AI, Dierich A, Vonesh JL, Gavériaux-Ruff C, Kieffer BL

Toward better pain control.

Scientific American

Basbaum AI, Julius D

Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity.

Journal of proteome research

Woods AS, Kaminski R, Oz M, Wang Y, Hauser K, Goody R, Wang HY, Jackson SN, Zeitz P, Zeitz KP, Zolkowska D, Schepers R, Nold M, Danielson J, Gräslund A, Vukojevic V, Bakalkin G, Basbaum A, Shippenberg T

Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord.

Neuroscience

Villeda SA, Akopians AL, Babayan AH, Basbaum AI, Phelps PE

TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.

Cell

Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D

Sustaining intrinsic growth capacity of adult neurons promotes spinal cord regeneration.

Proceedings of the National Academy of Sciences of the United States of America

Neumann S, Skinner K, Basbaum AI

Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system.

The Journal of biological chemistry

Högestätt ED, Jönsson BA, Ermund A, Andersson DA, Björk H, Alexander JP, Cravatt BF, Basbaum AI, Zygmunt PM

A new way to lose your nerve.

Science of aging knowledge environment : SAGE KE

Basbaum AI

Immunoreactive TRPV-2 (VRL-1), a capsaicin receptor homolog, in the spinal cord of the rat.

The Journal of comparative neurology

Lewinter RD, Skinner K, Julius D, Basbaum AI

Peptidergic nociceptors of both trigeminal and dorsal root ganglia express serotonin 1D receptors: implications for the selective antimigraine action of triptans.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Potrebic S, Ahn AH, Skinner K, Fields HL, Basbaum AI

Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis.

The journal of pain : official journal of the American Pain Society

Shields SD, Eckert WA, Basbaum AI

Preprotachykinin-A gene deletion protects mice against acute pancreatitis and associated lung injury.

American journal of physiology. Gastrointestinal and liver physiology

Bhatia M, Slavin J, Cao Y, Basbaum AI, Neoptolemos JP

Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences.

Proceedings of the National Academy of Sciences of the United States of America

Mitrovic I, Margeta-Mitrovic M, Bader S, Stoffel M, Jan LY, Basbaum AI

Transneuronal tracing of diverse CNS circuits by Cre-mediated induction of wheat germ agglutinin in transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America

Braz JM, Rico B, Basbaum AI

The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Zeitz KP, Guy N, Malmberg AB, Dirajlal S, Martin WJ, Sun L, Bonhaus DW, Stucky CL, Julius D, Basbaum AI

Impaired response to chemical irritation of the urinary tract in mice with disruption of the preprotachykinin gene.

Neuroscience letters

Kiss S, Yoshiyama M, Cao YQ, Basbaum AI, de Groat WC, Lecci A, Maggi CA, Birder LA

Molecular mechanisms of nociception.

Nature

Julius D, Basbaum AI

The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord.

Neuron

Chen ZF, Rebelo S, White F, Malmberg AB, Baba H, Lima D, Woolf CJ, Basbaum AI, Anderson DJ

PKCgamma contributes to a subset of the NMDA-dependent spinal circuits that underlie injury-induced persistent pain.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Martin WJ, Malmberg AB, Basbaum AI

Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway.

Nature medicine

Vergnolle N, Bunnett NW, Sharkey KA, Brussee V, Compton SJ, Grady EF, Cirino G, Gerard N, Basbaum AI, Andrade-Gordon P, Hollenberg MD, Wallace JL

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition.

Nature

Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, Chao MV, Julius D

Differential contribution of substance P and neurokinin A to spinal cord neurokinin-1 receptor signaling in the rat.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Trafton JA, Abbadie C, Basbaum AI

Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine.

British journal of pharmacology

Malmberg AB, Hedley LR, Jasper JR, Hunter JC, Basbaum AI

Hypoalgesia and hyperalgesia with inherited hypertension in the rat.

American journal of physiology. Regulatory, integrative and comparative physiology

Taylor BK, Roderick RE, St Lezin E, Basbaum AI

Postsynaptic signaling via the [mu]-opioid receptor: responses of dorsal horn neurons to exogenous opioids and noxious stimulation.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Trafton JA, Abbadie C, Marek K, Basbaum AI

The contribution of spinal cord neurokinin-1 receptor signaling to pain.

The journal of pain : official journal of the American Pain Society

Trafton JA, Basbaum AI

Impaired nociception and pain sensation in mice lacking the capsaicin receptor.

Science (New York, N.Y.)

Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D

Opioid inhibition of formalin-induced changes in plasma extravasation and local blood flow in rats.

Pain

Taylor BK, Peterson MA, Roderick RE, Tate J, Green PG, Levine JO, Basbaum AI

A locus and mechanism of action for associative morphine tolerance.

Nature neuroscience

Mitchell JM, Basbaum AI, Fields HL

Early antinociception delays edema but does not reduce the magnitude of persistent pain in the formalin test.

The journal of pain : official journal of the American Pain Society

Taylor BK, Basbaum AI

Pain genes?: natural variation and transgenic mutants.

Annual review of neuroscience

Mogil JS, Yu L, Basbaum AI

Spinal opioid analgesia: how critical is the regulation of substance P signaling?

The Journal of neuroscience : the official journal of the Society for Neuroscience

Trafton JA, Abbadie C, Marchand S, Mantyh PW, Basbaum AI

Hospital merger leaves clinical science intact.

Nature

Stryker MP, Basbaum A, DeFranco T, Herskowitz I, Yamamoto K

Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene.

Proceedings of the National Academy of Sciences of the United States of America

Liu H, Cao Y, Basbaum AI, Mazarati AM, Sankar R, Wasterlain CG

Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Honor P, Menning PM, Rogers SD, Nichols ML, Basbaum AI, Besson JM, Mantyh PW

Distinct neurochemical features of acute and persistent pain.

Proceedings of the National Academy of Sciences of the United States of America

Basbaum AI

Pain.

Current biology : CB

Basbaum AI, Woolf CJ

Immunohistochemical localization of GABA(B) receptors in the rat central nervous system.

The Journal of comparative neurology

Margeta-Mitrovic M, Mitrovic I, Riley RC, Jan LY, Basbaum AI

Neurons in the dorsal column white matter of the spinal cord: complex neuropil in an unexpected location.

Proceedings of the National Academy of Sciences of the United States of America

Abbadie C, Skinner K, Mitrovic I, Basbaum AI

Spinal mechanisms of acute and persistent pain.

Regional anesthesia and pain medicine

Basbaum AI

The cloned capsaicin receptor integrates multiple pain-producing stimuli.

Neuron

Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, Julius D

Pain: nocistatin spells relief.

Current biology : CB

Martin WJ, Malmberg AB, Basbaum AI

The effects of prior chronic stress on cardiovascular responses to acute restraint and formalin injection.

Brain research

Bhatnagar S, Dallman MF, Roderick RE, Basbaum AI, Taylor BK

Activation of coeruleospinal noradrenergic inhibitory controls during withdrawal from morphine in the rat.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Rohde DS, Basbaum AI

Primary afferent tachykinins are required to experience moderate to intense pain.

Nature

Cao YQ, Mantyh PW, Carlson EJ, Gillespie AM, Epstein CJ, Basbaum AI

Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Abbadie C, Trafton J, Liu H, Mantyh PW, Basbaum AI

Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma.

Science (New York, N.Y.)

Malmberg AB, Chen C, Tonegawa S, Basbaum AI

Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Malmberg AB, Brandon EP, Idzerda RL, Liu H, McKnight GS, Basbaum AI

Noxious cutaneous thermal stimuli induce a graded release of endogenous substance P in the spinal cord: imaging peptide action in vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Allen BJ, Rogers SD, Ghilardi JR, Menning PM, Kuskowski MA, Basbaum AI, Simone DA, Mantyh PW

Transneuronal labeling of a nociceptive pathway, the spino-(trigemino-)parabrachio-amygdaloid, in the rat.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Jasmin L, Burkey AR, Card JP, Basbaum AI

Neurokinin-1 receptor-immunoreactive sympathetic preganglionic neurons: target specificity and ultrastructure.

Neuroscience

Llewellyn-Smith IJ, Martin CL, Minson JB, Pilowsky PM, Arnolda LF, Basbaum AI, Chalmers JP

GABA-immunoreactive boutons contact identified OFF and ON cells in the nucleus raphe magnus.

The Journal of comparative neurology

Skinner K, Fields HL, Basbaum AI, Mason P

Persistent cardiovascular and behavioral nociceptive responses to subcutaneous formalin require peripheral nerve input.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Taylor BK, Peterson MA, Basbaum AI

Relationship between analgesia and extracellular morphine in brain and spinal cord in awake rats.

Brain research

Matos FF, Rollema H, Taiwo YO, Levine JD, Basbaum AI

Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation.

Science (New York, N.Y.)

Mantyh PW, DeMaster E, Malhotra A, Ghilardi JR, Rogers SD, Mantyh CR, Liu H, Basbaum AI, Vigna SR, Maggio JE

Morphological characterization of substance P receptor-immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalis.

The Journal of comparative neurology

Brown JL, Liu H, Maggio JE, Vigna SR, Mantyh PW, Basbaum AI

Co-injection of wheat germ agglutinin-HRP and choleragenoid-HRP into the sciatic nerve of the rat blocks transganglionic transport.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Liu H, Llewellyn-Smith IJ, Basbaum AI

Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Mantyh PW, Allen CJ, Ghilardi JR, Rogers SD, Mantyh CR, Liu H, Basbaum AI, Vigna SR, Maggio JE

Differential effects of morphine on noxious stimulus-evoked fos-like immunoreactivity in subpopulations of spinoparabrachial neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Jasmin L, Wang H, Tarczy-Hornoch K, Levine JD, Basbaum AI

Role of vagal afferents and spinal pathways modulating inhibition of bradykinin-induced plasma extravasation by intrathecal nicotine.

Journal of neurophysiology

Miao FJ, Jänig W, Dallman MF, Benowitz NL, Heller PH, Basbaum AI, Levine JD

Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn.

Proceedings of the National Academy of Sciences of the United States of America

Liu H, Wang H, Sheng M, Jan LY, Jan YN, Basbaum AI

Synaptic relationship between substance P and the substance P receptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors.

Proceedings of the National Academy of Sciences of the United States of America

Liu H, Brown JL, Jasmin L, Maggio JE, Vigna SR, Mantyh PW, Basbaum AI

Peptides and the primary afferent nociceptor.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Levine JD, Fields HL, Basbaum AI

Adrenal medullary modulation of the inhibition of bradykinin-induced plasma extravasation by intrathecal nicotine.

The Journal of pharmacology and experimental therapeutics

Miao FJ, Dallman MF, Benowitz NL, Basbaum AI, Levine JD

Sympathoadrenal contribution to nicotinic and muscarinic modulation of bradykinin-induced plasma extravasation in the knee joint of the rat.

The Journal of pharmacology and experimental therapeutics

Miao FJ, Benowitz NL, Basbaum AI, Levine JD

Construction of a microdialysis probe with attached microinjection catheter.

Journal of neuroscience methods

Frothingham EP, Basbaum AI

Medullary CO2 chemoreceptor neuron identification by c-fos immunocytochemistry.

Journal of applied physiology (Bethesda, Md. : 1985)

Sato M, Severinghaus JW, Basbaum AI

Ultrastructural evidence for GABA-mediated disinhibitory circuits in the spinal cord of the cat.

Neuroscience letters

Liu H, Llewellyn-Smith IJ, Pilowsky P, Basbaum AI

Opioid regulation of nociceptive and neuropathic pain.

Clinical neuropharmacology

Basbaum AI

Opiate analgesia. How central is a peripheral target?

The New England journal of medicine

Basbaum AI, Levine JD

Purinergic regulation of bradykinin-induced plasma extravasation and adjuvant-induced arthritis in the rat.

Proceedings of the National Academy of Sciences of the United States of America

Green PG, Basbaum AI, Helms C, Levine JD

The contribution of the nervous system to inflammation and inflammatory disease.

Canadian journal of physiology and pharmacology

Basbaum AI, Levine JD

High-dose epinephrine acts at alpha 2-adrenoceptors to suppress experimental arthritis.

Brain research

Coderre TJ, Basbaum AI, Helms C, Levine JD

Denervation-induced inflammation in the rat.

Neuroscience letters

Levine JD, Coderre TJ, White DM, Finkbeiner WE, Basbaum AI

Neural influences on synovial mast cell density in rat.

Journal of neuroscience research

Levine JD, Coderre TJ, Covinsky K, Basbaum AI

Neurogenic mechanism for symmetrical arthritis.

Lancet (London, England)

Levine JD, Basbaum AI

Epinephrine exacerbates arthritis by an action at presynaptic B2-adrenoceptors.

Neuroscience

Coderre TJ, Basbaum AI, Dallman MF, Helms C, Levine JD

Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Presley RW, Menétrey D, Levine JD, Basbaum AI

Effect of deafferentation on the levels of uric acid in the spinal cord of the rat.

Neuroscience letters

Weil-Fugazza J, Godefroy F, Basbaum AI

Beta 2-adrenergic mechanisms in experimental arthritis.

Proceedings of the National Academy of Sciences of the United States of America

Levine JD, Coderre TJ, Helms C, Basbaum AI

Contribution of the nervous system to the pathophysiology of rheumatoid arthritis and other polyarthritides.

Rheumatic diseases clinics of North America

Levine JD, Goetzl EJ, Basbaum AI

Distinct cellular and regional localization of immunoreactive protein kinase C in rat brain.

Proceedings of the National Academy of Sciences of the United States of America

Mochly-Rosen D, Basbaum AI, Koshland DE

Labelling of peripheral-type benzodiazepine binding sites in human brain with [3H]PK 11195: anatomical and subcellular distribution.

Brain research bulletin

Doble A, Malgouris C, Daniel M, Daniel N, Imbault F, Basbaum A, Uzan A, Guérémy C, Le Fur G

Clinical response to regional intravenous guanethidine in patients with rheumatoid arthritis.

The Journal of rheumatology

Levine JD, Fye K, Heller P, Basbaum AI, Whiting-O'Keefe Q

Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Levine JD, Dardick SJ, Roizen MF, Helms C, Basbaum AI

Bulbospinal projections in the primate: a light and electron microscopic study of a pain modulating system.

The Journal of comparative neurology

Basbaum AI, Ralston DD, Ralston HJ

Benzidine dihydrochloride as a chromogen for single- and double-label light and electron microscopic immunocytochemical studies.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Lakos S, Basbaum AI

The contribution of pain to disability in experimentally induced arthritis.

Arthritis and rheumatism

Dardick SJ, Basbaum AI, Levine JD

Immunoreactive dynorphin B in sacral primary afferent fibers of the cat.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Basbaum AI, Cruz L, Weber E

Identification of Aplysia neurons containing immunoreactive FMRFamide.

Neuropeptides

Brown RO, Gusman D, Basbaum AI, Mayeri E

The contribution of neurogenic inflammation in experimental arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Levine JD, Moskowitz MA, Basbaum AI

Hypothesis: the nervous system may contribute to the pathophysiology of rheumatoid arthritis.

The Journal of rheumatology

Levine JD, Collier DH, Basbaum AI, Moskowitz MA, Helms CA

Reflex neurogenic inflammation. I. Contribution of the peripheral nervous system to spatially remote inflammatory responses that follow injury.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Levine JD, Dardick SJ, Basbaum AI, Scipio E

Intraneuronal substance P contributes to the severity of experimental arthritis.

Science (New York, N.Y.)

Levine JD, Clark R, Devor M, Helms C, Moskowitz MA, Basbaum AI

Radioimmunocytochemistry using a tritiated goat anti-rabbit second antibody.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Glazer EJ, Ramachandran J, Basbaum AI

The peptidergic organization of the cat periaqueductal gray. II. The distribution of immunoreactive substance P and vasoactive intestinal polypeptide.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Moss MS, Basbaum AI

The peptidergic organization of the cat periaqueductal gray. I. The distribution of immunoreactive enkephalin-containing neurons and terminals.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Moss MS, Glazer EJ, Basbaum AI

Simultaneous ultrastructural localization of tritiated serotonin and immunoreactive peptides.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Basbaum AI, Glazer EJ, Lord BA

Enkephalin-immunoreactive perikarya in the cat raphe dorsalis.

Neuroscience letters

Moss MS, Glazer EJ, Basbaum AI

Serotonin neurons in nucleus raphe dorsalis and paragigantocellularis of the cat contain enkephalin.

Journal de physiologie

Glazer EJ, Steinbusch H, Verhofstad A, Basbaum AI

Differential origins of spinothalamic tract projections to medial and lateral thalamus in the rat.

The Journal of comparative neurology

Giesler GJ, Menétrey D, Basbaum AI

Intradendritic recordings from hippocampal neurons.

Proceedings of the National Academy of Sciences of the United States of America

Wong RK, Prince DA, Basbaum AI

Endogenous pain control mechanisms: review and hypothesis.

Annals of neurology

Basbaum AI, Fields HL

Brainstem control of spinal pain-transmission neurons.

Annual review of physiology

Fields HL, Basbaum AI

Nucleus raphe magnus inhibition of spinal cord dorsal horn neurons.

Brain research

Fields HL, Basbaum AI, Clanton CH, Anderson SD

Opiate and stimulus-produced analgesia: functional anatomy of a medullospinal pathway.

Proceedings of the National Academy of Sciences of the United States of America

Basbaum AI, Clanton CH, Fields HL

Nucleus raphe magnus: a common mediator of opiate- and stimulus-produced analgesia.

Transactions of the American Neurological Association

Fields HL, Anderson SD, Clanton CH, Basbaum AI

Ongoing activity in peripheral nerve: injury discharge.

Experimental neurology

Wall PD, Waxman S, Basbaum AI