As part of our organization’s launch, the Pain and Addiction Research Center worked closely with the UCSF Alcohol and Addiction Research Group to host a Pain and Addiction Research Retreat this December, 2019. The retreat featured basic science and clinical research talks by faculty, post-docs, and students, as well as a poster session showcasing the depth and breadth of current research in pain and addiction ongoing at UCSF.

You can access the program, speaker presentations, and recordings of the live-stream below. Attendees were asked to complete a post-retreat survey, to help determine the direction and scope of future research gatherings, research proposal working groups, and other collaborations that will drive the work of the Pain and Addiction Research Center forward. 

62% of survey respondents generated new ideas for experiments, and 59% of respondents made connections for scientific collaboration as a result of the retreat. 76% of respondents stated that they would participate in a future pain or addiction related research proposal working group. These responses highlight the PARC’s enormous potential to foster the necessary collaborations across disciplines that will generate solutions to some of our nation’s greatest public health challenges. 

Access Retreat Recording

tiny.ucsf.edu/yqHKXv

Program

Mark Schumacher: Intro PARC Initiative

 

Daniel Lowenstein: Campus Leadership Perspective

 

Chris Miaskowski: Chronic Pain and Its Impact

                                                

Paula Lum: Addiction and Its Impact

 

Kelly Knight: Structural Factors Affecting Patients with Co-Morbid Pain and Addiction

 

Theme 1

 

Clinician Talk - Case Presentation

Valerie Jackson: Chronic Pain and Clinical Behavior

 

PI Bench Science Talk

Zhonghui Guan: Chronic Pain Models in Animals

 

Q&A

Moderator: Jon Levine

 

Theme 2

 

Clinician Talk – Case Presentation

D. Andrew Tompkins: The Intersection of Pain and Addiction

 

Hot Topic Journal Club Presentation

Maggie Waung: Pain Relief – It Feels So Good

 

PI Bench Science Talk

Elyssa Margolis: A Novel CNS Circuit for Analgesia but Not Positive Reinforcement

 

Q&A

Moderator: Xiaoke Chen

 

Post-Doc Pain Poster Preview

Man-Cheung Lee: Microdeletion in a FAAH Pseudogene Identified in a Patient with High Anandamide Concentrations and Pain Insensitivity

 

Post-Doc Addiction Poster Preview

Jeffrey Moffat: Corticostriatal BDNF Signaling Moderates Alcohol Intake and Habitual Alcohol Seeking

 

Theme 3

 

Clinician Talk

Daniel Ciccarone: The Triple Wave Epidemic: Opioids, Heroin and Fentanyl

 

Clinician Talk – Case Presentation

Howard Kornfeld: Buprenorphine, Analgesia, and Opioid Use Disorder

 

Graduate Student Poster Preview

Reed Stein (Shoichet Lab): Ultra-Large Library Docking for Novel Ligand Discovery: Applications to the Melatonin and Cannabinoid Receptors

 

PI Bench Science Talk – Addiction

Damien Jullié: Opioid Receptor Function at the Cellular Level

 

Q&A

Moderator: Joshua Berke

 

Theme 4

 

CTSI – RFA Pilot Grant

Abigail Sidibe: Intersection of Pain and Addiction

 

Clinician Talk – Case Presentation

Mark Schumacher: Clinical Cases from the Wards: Intractable Neuropathic Pain

 

Faculty Pain Poster Preview

Kord Kober: Pain–Signaling Pathways in Breast Cancer Survivors with Taxol Induced Peripheral Neuropathy

 

Translational Talk

Michael Rowbotham: Neuropathic Pain and Opioids: Can Opioids Cause Pain?

 

Q&A

Moderator: Allan Basbaum

 

Wrap Up

Howard Fields

 

Posters

 

Pain

 

Kyle Self, Catherine Baxley, Joannalyn Delacruz, Shahrzad Hassanbeigi Daryani, Benjamin Ladd, Karen Seal, Jennifer Manuel, Brian Borsari.

Adaptation of the Motivational Interviewing Skills Code to Predict Opioid Use and Use of Alternative Pain Care Strategies in Veterans. 

 

Lee M-C, Xu Z, Sharma M, Eilers H, Kawamata T, Kober, K, and Schumacher M.

Transcription Factor Sp4 is Required for Hyperalgesic State Persistence and Defines a Nociceptive Transcriptome.

 

Penny Brennan, PhD.

Life Stressors: Elevations and Disparities among Older Adults with Pain.

 

Kober, K. M., Conley, Y. P., Schumacher, M., Topp, K., Paul, S. M., Levine, J. D., Miaskowski, C.

Pain Signaling Pathways in Breast Cancer Survivors with Taxol Induced Peripheral Neuropathy.

 

Gregory Nachtrab, Qian Wang, Manual Mohr, Xiaoke Chen.

Circuit Architecture of Descending Pain Modulation in Mouse.

 

Clayton H. McClintock, Murray B. Stein, Alan N. Simmons, and Irina A. Strigo.

Mindfulness is Related to Reduced Emotional Distance from Others and Chronic Pain Among Interpersonal Trauma Survivors.

 

Tia A. Tummino, Brian K. Shoichet, & Dave R. Kokel.

Merging target and phenotypic drug discovery approaches to identify novel modulators of central nervous system pain targets. 

 

Elizabeth Bruns MS MD(1), Deanna Beafus PhD(2), Barbara Wismer MD MPH(3), Kelly Knight PhD(1), Shelley Adler PhD(4), Maria Chao MPA DrPH(4).

1University of California, San Francisco, 2 School of Medicine, Wake Forest, 3San Francisco Department of Public Health, 4Osher Center for Integrative Medicine, University of California, San Francisco, CA.

"Out of a Dark Hole" - The Psychosocial (R)evolution of Chronic Pain Experiences of Vulnerable Patients Attending an Integrative Pain Management Program. 

 

Mijung Park PhD MPH RN & Susan Wang MS.

Comorbid Pain and Depression in the Asian American population.

 

Addiction

 

Katlin Silm, Jing Yang, Pamela F. Marcott, Cedric S. Asensio, Jacob Eriksen, Daryl A. Guthrie, Amy H. Newman, Christopher P. Ford, Robert H. Edwards.

Synaptic Vesicle Recycling Pathway Determines Neurotransmitter Content and Release Properties. 

 

Alexandra Haas, MFT, Emily Dauria, PhD, D. Andrew Tompkins, MD MHS.

Evaluating the Impact of Project HOUDINI LINK (Hospital Opioid Use Disorder treatment INItiation and LINKage to Care).

 

Sujatha Sankaran MD, Matt Tierney NP, John Hall MBA, Sirin Tgamol.

A pilot to decrease risk of opioid overdoses in hospitalized patients.

 

Pain and Addiction

 

Gadi Gilam, John A. Sturgeon, Dokyoung S. You, Ajay D. Wasan, Beth D. Darnall, and Sean C. Mackey.

Negative Affect–Related Factors Have the Strongest Association with Prescription Opioid Misuse in a Cross-Sectional Cohort of Patients with Chronic Pain. 

 

Joanna R. Sells, Heather Nye, Sarah A. Palyo.

A Proactive Perioperative Approach to Pain and Substance Use in Veterans. 

 

R. Ben-Shalom, J. Balewski, V. Baratham, A. Siththaranjan, H. Kyoung, K. Kim, H. Dong, K. J. Bender, K. E. Bouchard.

Using convolutional neural networks to predict ion channel conductances in neuronal biophysical models.

 

Damien Jullié, Aaron Marley, Mark von Zastrow.

Differential presynaptic downregulation of opioid receptors.

Speakers