
Director, PARC
Professor and Chief, Division of Pain Medicine
+1 415 502-7022
Dr. Schumacher's research focuses on the identification of novel analgesic targets in the peripheral nervous system to treat chronic pain without risk of addiction. Currently, he is investigating a class of transcription inhibitors previously used to treat cancer that now show promise to block pain from inflammation and nerve injury.
Publications
Peripheral Neuroinflammation and Pain: How Acute Pain Becomes Chronic.
Current neuropharmacology
N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes.
Journal of neuroinflammation
Long-Term Trends in Postoperative Opioid Prescribing, 1994 to 2014.
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews
Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors.
Journal of neuroimmunology
Deleterious Effects of Higher Body Mass Index on Subjective and Objective Measures of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors.
Journal of pain and symptom management
Age-related differences in patient-reported and objective measures of chemotherapy-induced peripheral neuropathy among cancer survivors.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Pain Management and Opioid Regulation: Continuing Public Health Challenges.
American journal of public health
Phenotypic Characterization of Paclitaxel-Induced Peripheral Neuropathy in Cancer Survivors.
Journal of pain and symptom management
Associations Between Perceived Stress and Chemotherapy-Induced Peripheral Neuropathy and Otoxicity in Adult Cancer Survivors.
Journal of pain and symptom management
Impact of chemotherapy-induced neurotoxicities on adult cancer survivors' symptom burden and quality of life.
Journal of cancer survivorship : research and practice
Hearing loss and tinnitus in survivors with chemotherapy-induced neuropathy.
European journal of oncology nursing : the official journal of European Oncology Nursing Society
America's Opioid Epidemic: Supply and Demand Considerations.
Anesthesia and analgesia
N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1.
Journal of immunology (Baltimore, Md. : 1950)
Chemotherapy-Induced Neuropathy in Cancer Survivors.
Journal of pain and symptom management
Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways.
F1000Research
The anticancer antibiotic mithramycin-A inhibits TRPV1 expression in dorsal root ganglion neurons.
Neuroscience letters
Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons.
Molecular pain
Cutaneous nerve transection for the management of intractable upper extremity pain caused by invasive squamous cell carcinoma.
Journal of pain and symptom management
Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction.
Anesthesiology
TRPV1 splice variants: structure and function.
Frontiers in bioscience (Landmark edition)
Transient receptor potential channels in pain and inflammation: therapeutic opportunities.
Pain practice : the official journal of World Institute of Pain
Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis.
The Journal of biological chemistry
Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor.
Journal of neurochemistry
Isolation of an mRNA binding protein homologue that is expressed in nociceptors.
The European journal of neuroscience
Opioid-induced respiratory depression: are 5-HT4a receptor agonists the cure?
Molecular interventions
The reversal of fentanyl-induced tolerance by administration of "small-dose" ketamine.
Anesthesia and analgesia
The stretch-inactivated channel, a vanilloid receptor variant, is expressed in small-diameter sensory neurons in the rat.
Neuroscience letters
Molecular cloning of an N-terminal splice variant of the capsaicin receptor. Loss of N-terminal domain suggests functional divergence among capsaicin receptor subtypes.
The Journal of biological chemistry
ATP receptors in sickness, pain and death.
Chemistry & biology